Inputs

Ensure units match the model: HbA1c in % (or select mmol/mol), OGTT 90-min glucose in mg/dl (or select mmol/l).

Description

The Progression Likelihood Score (PLS) stratifies progression rates in children with stage 1 disease. The variables needed to calculate the PLS are the 90-minute glucose during OGTT, the HbA1c, and the IA-2A category defined by IA-2A titre.

References

  1. Weiss, A., Zapardiel-Gonzalo, J., Voss, F., Jolink, M., Stock, J., Haupt, F., Kick, K., Welzhofer, T., Heublein, A., Winkler, C., Achenbach, P., Ziegler, A., Bonifacio, E., & Group, F. T. F. (2022). Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening. Diabetologia, 65(12), 2121–2131. https://doi.org/10.1007/s00125-022-05780-9
  2. Bonifacio, E., Scholz, M., Weiss, A., & Ziegler, A. (2026). Comparison of IA-2 Bridge ELISA and Radiobinding Assays for Progression Risk Assessment in Early-Stage Type 1 Diabetes. medRxiv. https://doi.org/10.64898/2026.01.26.26344598
  3. Weiss, A., Chakievska, L., Achenbach, P., Hergl, M., Hummel, S., Ott, R., Scholz, M., Winkler, C., Bonifacio, E., & Ziegler, A. (2025). Stratifying the rate of disease progression by progression likelihood scores in children and adolescents with stage 1 and stage 2 type 1 diabetes in Germany. Diabetes Care, 49(2), 352–360. https://doi.org/10.2337/dc25-2184